Translational control in the endoplasmic reticulum stress response
نویسندگان
چکیده
منابع مشابه
Endoplasmic Reticulum Stress Response in Arabidopsis Roots
Roots are the frontier of plant body to perceive underground environmental change. Endoplasmic reticulum (ER) stress response represents circumvention of cellular stress caused by various environmental changes; however, a limited number of studies are available on the ER stress responses in roots. Here, we report the tunicamycin (TM) -induced ER stress response in Arabidopsis roots by monitorin...
متن کاملCancer Microenvironment and Endoplasmic Reticulum Stress Response
Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechani...
متن کاملEndoplasmic reticulum stress response and transcriptional reprogramming
Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. As a protein folding compartment, the ER provides a high-fidelity quality control system to ensure that only correctly folded proteins are released from the ER and that unfolded and/or misfolded proteins are retained and degraded. A number of...
متن کاملGlobal mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response.
The stability of mRNAs undergoing translation has long been a controversial question. Here, we systematically investigate links between mRNA turnover and translation during the endoplasmic reticulum (ER) stress response, a process during which protein synthesis is potently regulated. cDNA array-based approaches to assess the stability and translational status of each mRNA were devised. First, E...
متن کاملGlycoprotein Quality Control and Endoplasmic Reticulum Stress.
The endoplasmic reticulum (ER) supports many cellular processes and performs diverse functions, including protein synthesis, translocation across the membrane, integration into the membrane, folding, and posttranslational modifications including N-linked glycosylation; and regulation of Ca2+ homeostasis. In mammalian systems, the majority of proteins synthesized by the rough ER have N-linked gl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2002
ISSN: 0021-9738
DOI: 10.1172/jci16784